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January 1, 1996Stem Cells

Protein Characteristics of Thrombopoietin

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Key result

The N-terminal domain of thrombopoietin, containing two disulfide bonds (Cys7-Cys151 and Cys29-Cys85), is essential for its biological activity, whereas the C-terminal domain is not directly required.

Authors

TKTakashi KatoVascular Medicine

Discussion

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Implication

May guide TPO mimetic engineering for thrombocytopenia; leaves open in vivo validation of domain effects.

PICO

I
Intervention / Comparator
Thrombopoietin (TPO) purification and structural characterization
O
Primary Outcome
TPO biological activity and structural characteristics

Cite This Study

Takashi Kato (1996) studied this question. Thrombopoietin (TPO) purification and structural characterization was evaluated on TPO biological activity and structural characteristics. The N-terminal domain of thrombopoietin, containing two disulfide bonds (Cys7-Cys151 and Cys29-Cys85), is essential for its biological activity, whereas the C-terminal domain is not directly required.

synapsesocial.com/papers/6a9b8dd2c12994f0dcbb007ahttps://doi.org/10.1002/stem.5530140718
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Also Consider

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  1. 1Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors1995 · 159 citations
  2. 2Cloning and Characterization of the Human Megakaryocyte Growth and Development Factor (MGDF) Gene1995 · 105 citations
  3. 3Purification of human megakaryocyte colony-stimulating factor (Meg-CSF) from urine of aplastic anemia patients1991 · 4 citations
  4. 4Murine erythropoietin gene: cloning, expression, and human gene homology.1986 · 186 citations
  5. 5Recombinant human megakaryocyte growth and development factor (rhumgdf), a ligand for c‐mpl, produces functional human platelets in vitro1995 · 98 citations