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July 28, 2002Molecular and Cellular BiologyOpen Access

Mice Lacking Skeletal Muscle Actin Show Reduced Muscle Strength and Growth Deficits and Die during the Neonatal Period

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Population

Mice with disrupted skeletal actin gene by homologous recombination, hemizygous, and wild-type littermates

Comparison

Disruption of the skeletal actin gene vs Wild-type and hemizygous littermates

Design

Preclinical

Follow-up

neonatal period (day 1 to 9)

Authors

KCKelly CrawfordRFRobert W. FlickLCL. Close

Discussion

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Overview

Does not alter clinical practice; leaves open actin isoform compensation in human myopathy models.

Structured PICO

P
Population
Mice with disrupted skeletal actin gene by homologous recombination (null mice), hemizygous, and wild-type littermates
I
Intervention
Disruption of the skeletal actin gene
C
Comparator
Wild-type and hemizygous littermates
O
Outcome
Survival, body weight, and force production in Extensor digitorum longus (EDL) musclesurrogate

Skeletal actin is essential for adequate skeletal muscle growth, function, and postnatal survival in mice, and its loss cannot be fully compensated by cardiac and vascular smooth-muscle actin.

Cite This Study

Crawford et al. (2002) studied this question.

synapsesocial.com/papers/6a20ee4f76382611e5181fe5https://doi.org/10.1128/mcb.22.16.5887-5896.2002
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