Why the study?
Does precocious expression of alpha-skeletal or alpha-cardiac actin alter myoblast morphology in mouse C2 myoblasts?
Population
Mouse C2 myoblasts
Comparison
Transfection with human alpha-skeletal actin… vs Control cells
Design
Preclinical
Authors
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Impairs myoblast spreading in vitro; leaves open actin isoform roles in human muscle development or disease.
Does precocious expression of alpha-skeletal or alpha-cardiac actin alter myoblast morphology in mouse C2 myoblasts?
Precocious expression of alpha-skeletal actin, but not alpha-cardiac actin, compromises myoblast morphology without affecting the ability to assemble stress-fibre-like structures.
Gunning et al. (1997) studied this question.