Key result
A novel CMR-conditional cardiac phantom successfully simulated cardiac mechanics and enabled the introduction and testing of interventional tools under real-time MRI guidance.
Why the study?
Major limitations and challenges regarding interventional CMR procedures continue to delay translation from pre-clinical studies to human application.
A novel CMR-conditional cardiac phantom successfully mimics human cardiac mechanics and enables realistic training and testing for interventional CMR procedures like right heart catheterization.
Interventional magnetic resonance imaging (MRI) procedures promise to open-up new vistas regarding clinically relevant diagnostic and/or therapeutic procedures in the field of cardiology. However, a number of major limitations and challenges regarding interventional cardiovascular magnetic resonance (CMR) procedures still delay their translation from pre-clinical studies to human application. A CMR-conditional cardiac phantom was constructed using MR-safe or -conditional materials only that is based on a unique modular composition allowing quick replacement of individual components. A maximal flow of 76 ml/sec in the aorta and 111 ml/sec in the pulmonary artery were measured, whereas the maximal flow velocity was 56 cm/sec and 89 cm/sec, respectively. A conventional wedge-pressure catheter was advanced over a MRI-conditional guidewire into the right ventricle and thereafter positioned in the pulmonary artery. Pulmonary artery pressure was measured, obtaining the following values for our cardiac phantom: max/min/mean = 16/10/12 mmHg. The presented CMR-conditional cardiac phantom is the first of its kind that does not only mimic cardiac mechanics with adjustable fluid pressure in a four chamber setup that is closely adapted to that of the human heart, but also enables introduction and testing of interventional tools such as guidewires and catheters.
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Bietenbeck et al. (2019) studied Interventional CMR training. CMR-conditional cardiac phantom was evaluated on Feasibility of CMR-guided right heart catheterization. A novel CMR-conditional cardiac phantom successfully simulated cardiac mechanics and enabled the introduction and testing of interventional tools under real-time MRI guidance.
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