Blast cells from one‐way mixed lymphocyte cultures (MLC) revert to lymphocytes in vitro and in vivo . The blast‐derived lymphocytes (BDL) respond promptly in second MLC to the original and H‐2 cross‐reactive stimulator cells. The peak response by primed cells takes place on the 2nd – 3rd culture day, as compared to 6th – 7th day by nonprimed cells. BDL do not respond to the mitogens, phytohemagglutinin or concanavalin A.
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Andersson et al. (1973) studied this question.
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