Key result
Colorectal cancer patients experienced a significantly increased risk of cardiovascular disease during the first year following diagnosis compared to the general population (SIR 1.45).
Why the study?
Evidence regarding the relationship between colorectal cancer and the risk of cardiovascular disease is limited.
Does a diagnosis of colorectal cancer increase the risk of cardiovascular disease compared to the general population?
Cohort (n=2,071,892)
Does a diagnosis of colorectal cancer increase the risk of cardiovascular disease compared to the general population?
Patients with colorectal cancer have a significantly increased risk of developing cardiovascular disease, particularly coronary heart disease, during the first 3 years following their cancer diagnosis.
May prompt early CVD monitoring after colorectal cancer diagnosis; leaves open need for prospective intervention trials.
PURPOSE: Evidence regarding the relationship between colorectal cancer and the risk of cardiovascular disease (CVD) is limited. Thus, in this study, we aimed to determine the standardised incidence ratio (SIR) of CVDs in colorectal cancer patients in Taiwan. METHODS: A population-based cohort study enrolling the incident colorectal cancer population based on the Cancer Registry Database from 2007 to 2016 was conducted (n = 94,233, mean age: 62.4 years, 43.0% women). New cases of CVD, including coronary heart disease and ischemic stroke, through 31 December 2018 were obtained from the National Health Insurance Research Database and National Death Registry. Compared with the general population (n = 1,977,659, mean age: 44.3 years, 49.6% women), age- and sex-specific SIRs for CVDs were calculated by the time since diagnosis. RESULTS: A total of 6852 cardiovascular events occurred in colorectal cancer patients during a median follow-up of 4.4 years. The SIR of CVD was highest in the first year after diagnosis (SIR: 1.45, 95% confidence interval: 1.39-1.50); however, this decreased to the same value as that of the general population in later years. Similar patterns were observed for the SIR of coronary heart disease. However, the SIR of ischemic stroke among colorectal cancer patients was low from the second year following cancer diagnosis. CONCLUSIONS: Colorectal cancer patients are at an increased risk of developing CVD, especially coronary heart disease, during the first 3 years following colorectal cancer diagnosis.
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Hsu et al. (2022) conducted a cohort in Colorectal cancer (n=2,071,892). Colorectal cancer vs. General population was evaluated on First major cardiovascular event (hospitalisation for coronary heart disease, arterial revascularisation procedure, hospitalisation for ischemic stroke, or confirmed death from coronary heart disease or ischemic stroke) (SIR 1.45, 95% CI 1.39-1.50). Colorectal cancer patients experienced a significantly increased risk of cardiovascular disease during the first year following diagnosis compared to the general population (SIR 1.45).
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