Why the study?
Does continuous long-term anticoagulant therapy improve survival rates in patients with prior myocardial infarction or coronary occlusions?
Does continuous long-term anticoagulant therapy improve survival rates in patients with prior myocardial infarction or coronary occlusions?
Continuous long-term anticoagulant therapy is suggested to provide survival value for patients with prior myocardial infarction, despite bleeding risks.
Should not yet change post-MI anticoagulation practice; leaves open need for RCTs to confirm survival benefit versus bleeding.
Evidence is set forth to show the value of continuous long-term anticoagulant therapy by comparison with a control group of patients who have also had multiple coronary occlusions or single infarcts, followed by severe angina pectoris or episodes of coronary failure. Statistical life-estimate determinations are included. Bleeding complications are encountered less frequently with improved methods of management and are considered a justifiable risk, in view of the serious consequences of the natural progress of the disease. After a program of long-term anticoagulant treatment has been instituted, cessation of therapy may be hazardous.
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Keyes et al. (1956) studied this question.
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