August 1, 1998GeneticsOpen Access

Sro7p, a Saccharomyces cerevisiae Counterpart of the Tumor Suppressor l(2)gl Protein, Is Related to Myosins in Function

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Population

Saccharomyces cerevisiae (yeast) strains including sro7Delta sro77Delta, myo1Delta, and myo2 mutants

Design

Preclinical

Authors

Discussion

Yeast Sro7-myosin interactions remain preclinical; leaves open whether l(2)gl homologs regulate cardiac cytoskeletal function in mammals.

Population

Saccharomyces cerevisiae (yeast) strains including sro7Delta sro77Delta, myo1Delta, and myo2 mutants

Intervention

Genetic deletion or overexpression of SRO7, SRO77, MYO1, MYO2, and expression of human l(2)gl counterpart

Outcome

Cell polarity, actin cytoskeleton organization, and cold-sensitive growth phenotype

Sro7p and Sro77p are yeast counterparts of the Drosophila tumor suppressor l(2)gl and interact with myosins to regulate cellular pathways.

Kagami et al. (1998) studied this question.

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