Population
Skinned single skeletal muscle fibers
Comparison
Incubation with N-ethylmaleimide- modified… vs Untreated fibers or different calcium…
Design
Preclinical
Authors
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No clinical implications yet; leaves open whether strong-binding cross-bridges can be targeted to modulate cardiac force.
Strong-binding myosin cross-bridges are involved in the activation of the thin filament and contribute to the cooperativity observed in Ca2+ activation of force.
Swartz et al. (1992) studied this question.
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