Key result
Complete TnC extraction reduces the maximum substrate-induced tension by 25% and reduces the maximum Ca2+ induced tension to zero in skinned rabbit psoas fibers.
TnC extraction demonstrates that co-operative activation of skeletal muscle thin filaments by rigor crossbridges depends on contiguous, intact Tn-Tm complexes.
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Skinned rabbit fiber results should not change clinical practice; leaves open whether contiguous Tn-Tm complexes are required for cooperative activation in human myocardium.
Brandt et al. (1990) studied this question. TnC extraction vs. Control skinned rabbit psoas fibers was evaluated on Slope (ns) of the bell-shaped pS/tension relationship. Complete TnC extraction reduces the maximum substrate-induced tension by 25% and reduces the maximum Ca2+ induced tension to zero in skinned rabbit psoas fibers.
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