February 16, 2026Blood Vessels Thrombosis & HemostasisOpen Access

Dimethyl sulfoxide acutely induces shear-dependent thrombosis in flow assays via red blood cell–dependent mechanisms

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Key result

Dimethyl sulfoxide acutely induces massive red blood cell-dependent platelet aggregation under arterial shear conditions.

Population

microfluidic and flow-based thrombosis assays

Design

Preclinical

Authors

SRSavindi De Zoysa RamasundaraThe University of Sydney ASAllan SunThe University of Sydney MEMarc EllisThe University of Sydney

Discussion

Member takes

Implication

Alerts researchers to DMSO artifact in shear platelet assays; leaves open re-evaluation of prior vehicle-controlled hemostasis data.

Structured PICO

Population

microfluidic and flow-based thrombosis assays

Intervention

Dimethyl sulfoxide (DMSO)

Outcome

platelet aggregation under arterial shear conditionssurrogate

DMSO, a common vehicle solvent, induces massive platelet aggregation in flow assays, highlighting a critical methodological artifact in hemostasis research.

Cite This Study

Ramasundara et al. (2026) studied this question. Dimethyl sulfoxide acutely induces massive, red blood cell-dependent platelet aggregation under arterial shear conditions in a dose-, time-, and shear-dependent manner.

synapsesocial.com/papers/6a20f7cb10699ec7be2acafc https://doi.org/10.1016/j.bvth.2026.100149

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Dimethyl sulfoxide acutely induces shear-dependent thrombosis in flow assays via red blood cell–dependent mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dimethyl sulfoxide acutely induces shear-dependent thrombosis in flow assays via red blood cell–dependent mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider