Randomized trial assesses toxicity, mutagenicity, and estrogenicity of bisphenol-A degradation products, suggesting low risk.
Key Points
This research aims to evaluate the acute toxicity, mutagenicity, and estrogenicity of bisphenol-A biodegradation products.
Examined acute toxicity using Daphtoxkit on Daphnia magna.
Assessed mutagenicity using the umu test system.
Determined estrogenicity through a yeast two-hybrid system.
BPA exhibited moderate toxicity to Daphnia magna (EC(50) 10 mg/L) and weak estrogenicity, significantly lower than 17beta-estradiol (5 orders of magnitude).
All tested BPA biodegradation products showed very low acute toxicity compared to BPA and were not mutagenic.
A slight estrogenic activity was detected for p-hydroxyacetophenone among degradation products.