Key result
Fructose supplementation completely abrogated the 2-deoxyglucose-induced prolongation of cardiomyocyte contraction and relaxation phases, and prevented the Ca2+ transient delay (23.7 ms vs 29.0 ms, p<0.05).
Why the study?
Does acute fructose exposure modulate excitation-contraction coupling and Ca2+ handling in isolated adult rat cardiomyocytes?
Population
Isolated ventricular cardiomyocytes from adult male Sprague Dawley rats
Comparison
Fructose buffer superfusion for 2-3 minutes vs Standard glucose buffer and glucose metabolic…
Design
Preclinical
Follow-up
2-3 minutes
Authors
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Acute fructose may modulate rat cardiomyocyte Ca2+ handling under stress; hypothesis-generating and leaves open human cardiac relevance.
Does acute fructose exposure modulate excitation-contraction coupling and Ca2+ handling in isolated adult rat cardiomyocytes?
Absolute Event Rate: 23.7% vs 29%
p-value: p=<0.05
This study provides the first evidence that cardiomyocytes express the GLUT5 transporter and can acutely utilize exogenous fructose to modulate excitation-contraction coupling.
Mellor et al. (2011) studied Healthy cardiomyocytes. Fructose vs. 2-deoxyglucose (11 mM) alone was evaluated on Time to peak Ca2+ transient (p=<0.05). Fructose supplementation completely abrogated the 2-deoxyglucose-induced prolongation of cardiomyocyte contraction and relaxation phases, and prevented the Ca2+ transient delay (23.7 ms vs 29.0 ms, p<0.05).
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