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July 1, 1986The Journal of Cell BiologyOpen Access

Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa.

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Authors

PNPeter J. NewmanMedical College of Wisconsin YKY KawaiTohoku University RMRobert R. MontgomeryMedical College of Wisconsin

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Implication

Suggests GP IIb/IIIa as antithrombotic target; leaves open prospective trials in cardiovascular disease.

Key Points

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Cite This Study

Newman et al. (1986) studied this question.

synapsesocial.com/papers/6a20f8aff76165bc1becd7e1 https://doi.org/10.1083/jcb.103.1.81

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Molecular Defects in Interactions of Platelets with the Vessel Wall1984 · 375 citations
2Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.1984 · 85 citations
3Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells1973 · 1,291 citations
4Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies.1983 · 235 citations
5Interaction of von Willebrand factor with human platelets in the plasma milieu.1984 · 96 citations