Key result
Cardiovascular measures maintain robust phenotypic stability across repeated total sleep deprivation and recovery.
Why the study?
The authors sought to determine whether cardiovascular measures show trait-like responses after repeated total sleep deprivation, baseline, and recovery exposures across long-duration studies.
Do cardiovascular measures show robust phenotypic stability across long-duration intervals involving repeated sleep deprivation and recovery in healthy adults?
Do cardiovascular measures show robust phenotypic stability across long-duration intervals involving repeated sleep deprivation and recovery in healthy adults?
Cardiovascular measures such as stroke volume, heart rate, and cardiac index demonstrate robust intra-individual stability over up to 8 months of repeated sleep deprivation and recovery, suggesting their utility as reliable physiological biomarkers.
Supports cardiovascular measures as reliable biomarkers in sleep research; leaves open validation in clinical populations before any practice implications.
Introduction We determined whether cardiovascular (CV) measures show trait-like responses after repeated total sleep deprivation (TSD), baseline (BL) and recovery (REC) exposures in two long-duration studies (total N = 11 adults). Methods A 5-day experiment was conducted twice at months 2 and 4 in a 4-month study ( N = 6 healthy adults; 3 females; mean age ± SD, 34.3 ± 5.7 years; mean BMI ± SD, 22.5 ± 3.2 kg/m 2 ), and three times at months 2, 4, and 8 in an 8-month study ( N = 5 healthy adults; 2 females; mean age ± SD, 33.6 ± 5.17 years; mean BMI ± SD, 27.1 ± 4.9 kg/m 2 ). Participants were not shift workers or exposed to TSD in their professions. During each experiment, various seated and standing CV measures were collected via echocardiography [stroke volume (SV), heart rate (HR), cardiac index (CI), left ventricular ejection time (LVET), and systemic vascular resistance index (SVRI)] or blood pressure monitor [systolic blood pressure (SBP)] after (1) two BL 8h time in bed (TIB) nights; (2) an acute TSD night; and (3) two REC 8–10 h TIB nights. Intraclass correlation coefficients (ICCs) assessed CV measure stability during BL, TSD, and REC and for the BL and REC average (BL + REC) across months 2, 4, and 8; Spearman’s rho assessed the relative rank of individuals’ CV responses across measures. Results Seated BL (0.693–0.944), TSD (0.643–0.962) and REC (0.735–0.960) CV ICCs showed substantial to almost perfect stability and seated BL + REC CV ICCs (0.552–0.965) showed moderate to almost perfect stability across months 2, 4, and 8. Individuals also exhibited significant, consistent responses within seated CV measures during BL, TSD, and REC. Standing CV measures showed similar ICCs for BL, TSD, and REC and similar response consistency. Discussion This is the first demonstration of remarkably robust phenotypic stability of a number of CV measures in healthy adults during repeated TSD, BL and REC exposures across 2, 4, and 8 months, with significant consistency of responses within CV measures. The cardiovascular measures examined in our studies, including SV, HR, CI, LVET, SVRI, and SBP, are useful biomarkers that effectively track physiology consistently across long durations and repeated sleep deprivation and recovery.
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Pasetes et al. (2023) studied Healthy (n=11). Total sleep deprivation vs. Baseline and recovery sleep was evaluated on Phenotypic stability of seated cardiovascular measures (intraclass correlation coefficients) during total sleep deprivation. Cardiovascular measures including stroke volume, heart rate, cardiac index, left ventricular ejection time, systolic blood pressure, and systemic vascular resistance index displayed robust phenotypic stability (ICCs 0.643-0.962) across long-duration intervals involving repeated total sleep deprivation and recovery.
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