Key result
Upper limb tasks reveal weaker cortical responses and reduced motor activation in MCI versus controls.
Why the study?
Early detection and intervention are crucial to preventing Alzheimer's disease progression in mild cognitive impairment.
Does the integration of upper limb multimodal tasks with fNIRS assess cognitive and motor functions in MCI patients?
Observational (n=37)
Does the integration of upper limb multimodal tasks with fNIRS assess cognitive and motor functions in MCI patients?
ULMTs combined with fNIRS show potential for early assessment and intervention in mild cognitive impairment by detecting differences in cortical and motor responses.
fNIRS with upper limb tasks may detect MCI cortical differences; hypothesis-generating and should not yet change practice.
Mild cognitive impairment (MCI) is primarily characterized by a gradual decline in cognitive function, where early detection and intervention are crucial to preventing Alzheimer's disease progression. This study integrates upper limb multimodal tasks (ULMTs) with functional near-infrared spectroscopy (fNIRS) to assess cognitive and motor functions in MCI patients. Thirty-seven elderly participants were categorized into healthy control (HC) and MCI groups. The experiment consisted of resting state, numerical cognitive task (NCT), motor task (MT), and ULMT phases. fNIRS measured hemodynamic responses in the prefrontal and motor cortices, while an upper limb trainer recorded motor data. Results showed weaker cortical responses in the MCI group during rest and reduced motor cortex activation during NCT. Both groups displayed increased cortical activity during ULMT compared to NCT but reduced motor performance compared to MT. These findings demonstrate the potential of ULMTs combined with fNIRS for early MCI assessment and intervention.
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You et al. (2025) conducted an observational in Mild cognitive impairment (MCI) (n=37). Upper limb multimodal tasks (ULMTs) combined with fNIRS vs. Healthy controls was evaluated on Hemodynamic responses in the prefrontal and motor cortices and motor performance. Upper limb multimodal tasks combined with fNIRS revealed weaker cortical responses in MCI patients during rest and reduced motor cortex activation during numerical cognitive tasks compared to controls.
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