Why the study?
Patients with MCI are at high risk for future dementia, but early identification and active intervention could reduce morbidity and dementia incidence.
Does functional near-infrared spectroscopy (fNIRS) combined with a modified Wisconsin card sorting test detect differences in prefrontal cortex hemodynamics in patients with mild cognitive impairment?
Does functional near-infrared spectroscopy (fNIRS) combined with a modified Wisconsin card sorting test detect differences in prefrontal cortex hemodynamics in patients with mild cognitive impairment?
fNIRS combined with a modified Wisconsin card sorting test can detect differences in prefrontal cortex hemodynamics among patients with varying degrees of cognitive impairment and stroke.
fNIRS may support noninvasive MCI detection clinically; leaves open validation in larger prospective studies before adoption.
Patients with mild cognitive impairment (MCI) are at a high risk of developing future dementia. However, early identification and active intervention could potentially reduce its morbidity and the incidence of dementia. Functional near-infrared spectroscopy (fNIRS) has been proposed as a noninvasive modality for detecting oxygenation changes in the time-varying hemodynamics of the prefrontal cortex. This study sought to provide an effective method for detecting patients with MCI using fNIRS and the Wisconsin card sorting test (WCST) to evaluate changes in blood oxygenation. The results revealed that all groups with a lower mini-mental state examination grade had a higher increase in HHb concentration during a modified WCST (MCST). The increase in the change in oxygenated hemoglobin concentration in the stroke group was smaller than that in the normal group due to weak cerebrovascular reactivity.
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Huang et al. (2023) studied this question.
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