Literature Review and a Series of Cinical Cases of Castleman’s Disease in Children

Background. Castleman’s disease (CD) in children is represented, as a rule, by a local form and a hyaline-vascular morphological variant. The choice of therapeutic options is difficult due to the lack of uniform treatment standards. Given the benign course, cytostatic therapy is not used. The choice of treatment method for patients with CD in most cases is determined by the prevalence of the process. In case of local form of CD, surgical treatment is carried out in the scope of radical removal of the affected lymph nodes; if surgical treatment is ineffective, radiation therapy is considered. Clinical observations description. In 2011–2024 it was observed 9 patients aged 1 to 17 years with morphologically verified unicentric CD. All patients underwent incisional biopsy; the hyaline-vascular variant was detected in 6 patients, and the plasma cell variant — in 3 patients. The duration of the medical history was 2–56 months. Relapse of the disease after primary surgical treatment occurred in a single case. Conclusion. Lymphadenopathy and various types of lymphoid hyperplasia are traditionally difficult in differential diagnosis in the practical work of a pediatrician, since it can be manifestations of a wide range of infectious, inflammatory, immune and malignant diseases. A special place in the large list of pathologies accompanied by enlarged lymph nodes is occupied by rare diseases, which include CD. For timely and correct CD diagnosis it is necessary to analyze the anamnesis, use an instrumental method for disease dissemination study and necessary a morphologic verification.