Key result
Six additional VGCC beta subunit homologs were identified in zebrafish, primarily expressed in the nervous system and developing heart, suggesting three pairs of duplicate genes.
Findings remain preclinical; leaves open new avenues for modeling VGCC beta subunits in vertebrate cardiac development.
Voltage-gated calcium channels (VGCC) play important roles in electrically excitable cells and embryonic development. The VGCC beta subunits are essential for membrane localization of the channel and exert modulatory effects on channel functions. In mammals, the VGCC beta subunit gene family contains four members. In zebrafish, there appear to be seven VGCC beta subunits including the previously identified beta1 subunit. cDNAs for six additional VGCC beta subunit homologs were identified in zebrafish, their chromosomal locations determined and their expression patterns characterized during embryonic development. These six genes are primarily expressed in the nervous system with cacnb4a also expressed in the developing heart. Sequence homology, genomic synteny and expression patterns suggest that there are three pairs of duplicate genes for beta2, beta3, and beta4 in zebrafish with distinct expression patterns during embryonic development.
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Zhou et al. (2008) studied Embryonic development. Identification of VGCC beta subunits was evaluated on Identification, chromosomal locations, and expression patterns of VGCC beta subunits. Six additional VGCC beta subunit homologs were identified in zebrafish, primarily expressed in the nervous system and developing heart, suggesting three pairs of duplicate genes.
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