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Backgrounds: L-type voltage-dependent calcium channel (LTCC) plays a crucial role in insulin secretion from pancreatic cells through Ca 2+ influx. In the recent report, LTCC Cav1.3 subtype homozygous knock out mice showed impairment of postnatal pancreatic beta cell development as well as insulin secretion.
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Choi et al. (2007) studied this question.
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