Why the study?
Does Cx40 deficiency affect atrial conduction and activation times in developing murine atria?
Does Cx40 deficiency affect atrial conduction and activation times in developing murine atria?
Connexin40 plays a crucial physiological role in developing murine atria, as its deficiency leads to prolonged activation times and ectopic impulse origins.
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Cx40 deficiency impairs murine atrial conduction; leaves open relevance to human developmental arrhythmias.
Connexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria.
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Beneš et al. (2014) studied Atrial conduction development. Cx40 deficiency vs. Normal Cx40 expression was evaluated on Atrial activation times during spontaneous activation.
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