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September 19, 2023PsychogeriatricsOpen Access

Association between longitudinal changes in striatal dopamine transporter uptake and clinical features of dementia with Lewy bodies

Ryō Yamamoto Naoto Takenoshita Yuta Inagawa Hikaru Kato Kyoko Kaneshiro Tomoki Kamiya Shoya Inagawa Aya Saisho Akito Tsugawa Yukari Mastumoto Mana Yoshimura Kazuhiro Saito Soichiro Shimizu T. Sato

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Key Points

This study aims to explore how changes in dopamine transporter uptake relate to cognitive and motor symptoms in patients with dementia with Lewy bodies.
35 outpatients with probable DLB underwent DaT-SPECT at two time points.
Correlations between changes in DaT uptake and clinical features were analyzed over time.
Follow-up period spanned from April 2014 to September 2020.
Significant correlation between annual changes in parkinsonism severity and DaT uptake in the left posterior putamen (r = -0.39, P = 0.03).
Mini-Mental State Examination scores showed a correlation with DaT uptake in all regions except the right posterior putamen (P < 0.05).
Findings suggest a crucial pathway from the ventrolateral substantia nigra to the putamen for motor function in DLB.

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Implication

Investigates link between DaT uptake and cognition in dementia with Lewy bodies, suggesting significant correlations.

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Cite This Study

Yamamoto et al. (2023) studied this question.

synapsesocial.com/papers/6a21025638e21729bad68884 https://doi.org/10.1111/psyg.13025

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