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This research aims to understand how the short gastrulation gene influences dorsal-ventral patterning in Drosophila embryos.

November 1, 1994Genes & DevelopmentOpen Access

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

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This research aims to understand how the short gastrulation gene influences dorsal-ventral patterning in Drosophila embryos.
Phenotypic characterization of sog mutant embryos in dorsal and lateral regions.
Cloning of the sog locus and analysis of its gene expression patterns.
Investigation of the Sog protein structure and potential cleavage processes.
Sog antagonizes dpp activity specifically in ventral cells, affecting dorsal patterning.
Sog is expressed in a lateral stripe, adjacent to dpp-expressing dorsal cells.
Proposed cleavage of Sog may release peptides that diffuse and regulate Dpp functions.

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Randomized trial investigates dorsal-ventral patterning regulation in Drosophila embryos, suggesting Sog antagonizes Dpp activity.

François et al. (1994) studied this question.

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