Key result
Serum biomarkers including GDF-15 were significantly higher in CAD patients and increased exponentially with decreasing EF, with GDF-15 independently associated with EF (p=0.009).
Why the study?
Various biomarkers have been associated with coronary artery disease and ischemic heart failure, but their correlation with left ventricular ejection fraction needed investigation.
Observational (n=361)
p-value: p=0.009
GDF-15, along with NT-proBNP, is independently associated with left ventricular ejection fraction in patients with coronary artery disease, suggesting its potential utility as a biomarker for diagnosis and clinical follow-up.
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GDF-15 may complement EF assessment in CAD; leaves open its diagnostic utility pending prospective validation.
Dalos et al. (2019) conducted an observational in Coronary artery disease (n=361). Serum biomarkers (suPAR, GDF-15, H-FABP, sST2) vs. Healthy controls was evaluated on Association with left ventricular ejection fraction (p=0.009). Serum biomarkers including GDF-15 were significantly higher in CAD patients and increased exponentially with decreasing EF, with GDF-15 independently associated with EF (p=0.009).
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