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This research aims to explore the impact of chemical modifications on the structure and function of the Na(+)-K(+)-ATPase protein.

Chemical modification as an approach to elucidation of sodium pump structure-function relations

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This research aims to explore the impact of chemical modifications on the structure and function of the Na(+)-K(+)-ATPase protein.
Chemical modification of specific residues in the Na(+)-K(+)-ATPase protein.
Use of inhibitors, ligands, modifiers, and proteolytic enzymes to study enzyme activity and kinetics.
Analysis of enzyme structure and conformational states based on modification techniques.
Chemical modifications provided extensive data on the kinetics and structure of the Na(+)-K(+)-ATPase protein.
A variety of reagents and approaches were reviewed for obtaining structure-function correlates.
The findings will inform future mutagenesis studies with new expression systems.

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The article discusses how chemical modifications aid in understanding enzyme function in sodium pumps, suggesting future research directions.

Pedemonte et al. (1990) studied this question.

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The article discusses how chemical modifications aid in understanding enzyme function in sodium pumps, suggesting future research directions.