What question did this study set out to answer?

The aim is to investigate the role of TGF-beta in the proliferation of macrophages under different conditions.

February 1, 1992The Journal of ImmunologyOpen Access

Transforming growth factor-beta enhances the M-CSF and GM-CSF-stimulated proliferation of macrophages

View Full Paper

Ask AI

Bookmark

Authors

ACAntonio CeladaUniversitat de Barcelona RMRichard A. MakiSanford Burnham Prebys Medical Discovery Institute

Discussion

Member takes

Implication

Randomized trial shows that TGF-beta enhances proliferation of macrophages in presence of M-CSF and GM-CSF, indicating its dual role in bone marrow and tissues.

Key Points

The aim is to investigate the role of TGF-beta in the proliferation of macrophages under different conditions.
Examined the effect of TGF-beta on murine macrophages in liquid culture.
Analyzed proliferation responses of bone marrow-derived macrophages (BMM) to M-CSF and GM-CSF in presence of TGF-beta.
Evaluated the impact of TGF-beta antibody on proliferation rates.
TGF-beta enhanced M-CSF and GM-CSF-stimulated proliferation of differentiated BMM.
Inhibition of M-CSF-dependent proliferation by TGF-beta antibody reduced proliferation by 32%.
TGF-beta had an inhibitory effect on nonadherent BMM proliferation after 3 days in culture.

Cite This Study

Celada et al. (1992) studied this question.

synapsesocial.com/papers/6a210834202ec1db3916dc19 https://doi.org/10.4049/jimmunol.148.4.1102

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial shows that TGF-beta enhances proliferation of macrophages in presence of M-CSF and GM-CSF, indicating its dual role in bone marrow and tissues.

Transforming growth factor-beta enhances the M-CSF and GM-CSF-stimulated proliferation of macrophages

Discussion

Member takes

Implication

Key Points

Cite This Study

Transforming growth factor-beta enhances the M-CSF and GM-CSF-stimulated proliferation of macrophages

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider