August 1, 1981BloodOpen Access

The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by prostaglandin I2

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Why the study?

Does prostaglandin I2 infusion reduce platelet attachment and secretion following balloon deendothelialization in a rabbit aorta model?

Population

Rabbit aorta model following balloon deendothelialization

Comparison

Prostaglandin I2 infusion vs No infusion/baseline state (implied)

Design

Preclinical

Follow-up

up to 1 hour after injury

Authors

BAB Adelman MSM B StemermanUniversity of California, Riverside DMD Mennell

Discussion

Member takes

Implication

Does not support clinical use; leaves open translation of PGI2 effects from rabbit vascular injury models.

Structured PICO

Does prostaglandin I2 infusion reduce platelet attachment and secretion following balloon deendothelialization in a rabbit aorta model?

Population

Rabbit aorta model following balloon deendothelialization

Intervention

Prostaglandin I2 infusion (650-850 ng/kg/min or 50-100 ng/kg/min)

Comparator

No infusion/baseline state (implied)

Outcome

Platelet attachment to the subendothelium, surface coverage, and platelet factor 4 secretionsurrogate

High-dose prostaglandin I2 effectively inhibits platelet aggregation and attachment to the subendothelium following balloon injury in a rabbit model.

Cite This Study

Adelman et al. (1981) studied this question.

synapsesocial.com/papers/6a210d93bbda06802a967889 https://doi.org/10.1182/blood.v58.2.198.198

View Full Paper

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The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by prostaglandin I2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by prostaglandin I2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider