Why the study?
Does NOS inhibition with L-NAME reduce insulin-mediated glucose disposal in normal rats?
Population
Normal rats
Comparison
NOS inhibitor NG-nitro-L-arginine methyl ester… vs Saline infused constantly during a…
Design
Preclinical
Authors
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NOS blockade reduces glucose disposal in rats; extends preclinical NO-insulin links but leaves open human translation.
Does NOS inhibition with L-NAME reduce insulin-mediated glucose disposal in normal rats?
In vivo NOS blockade with L-NAME significantly reduces insulin-stimulated glucose uptake in skeletal muscles, heart, and adipose tissues in rats, suggesting insulin action in these tissues is NO-dependent.
Roy et al. (1998) studied this question.
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