Key result
Daily oral CBD fails to improve fitness, body composition, mental health, or CRP versus placebo.
Why the study?
There is a lack of research on the effects of cannabidiol on health-related fitness, physical activity, cognitive health, psychological wellbeing, and C-reactive protein concentrations in healthy individuals.
Does oral cannabidiol improve health-related fitness, physical activity, cognitive health, psychological wellbeing, and CRP concentrations in healthy adults?
RCT (n=48)
randomized
Does oral cannabidiol improve health-related fitness, physical activity, cognitive health, psychological wellbeing, and CRP concentrations in healthy adults?
Eight weeks of 50 mg daily oral cannabidiol supplementation did not significantly alter measures of health-related fitness, mental health, or inflammation in healthy adults, though it may prevent declines in anaerobic fitness.
Answers are grounded in this paper and cite their sources.
No benefit from 50 mg daily oral CBD on fitness or mental health in healthy adults; reinforces null effects and directs research to other doses or populations.
BACKGROUND: There is a lack of research on the effects of cannabidiol (CBD) on health-related fitness, physical activity, cognitive health, psychological wellbeing, and concentrations of C-reactive protein (CRP) in healthy individuals. CBD has potential anti-inflammatory and neuroprotective effects. METHODS: This study aimed to investigate the effects of 8 weeks of CBD on the above-mentioned measures in healthy individuals. Forty-eight participants were randomized into two groups receiving either oral capsules of 50 mg of CBD or a calorie-matched placebo daily. Participants completed pre- and post-intervention assessments, including blood draws, body composition, fitness, physical activity, and self-reported surveys. RESULTS: There were no significant differences between groups regarding body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. However, the placebo group experienced a decline in mean peak power and relative peak power compared to the CBD group. CONCLUSIONS: The results suggest that 8 weeks of CBD supplementation may prevent declines in anaerobic fitness over time. However, long-term CBD supplementation may not be beneficial for altering measures of health-related fitness, mental health, and inflammation in healthy individuals.
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Flores et al. (2023) conducted an RCT in Healthy adults (n=48). Oral Cannabidiol (CBD) vs. calorie-matched placebo was evaluated on body composition, aerobic fitness, muscular strength, physical activity, cognitive health, psychological wellbeing, and resting CRP concentrations. Eight weeks of daily oral CBD did not alter body composition, aerobic fitness, mental health, or resting CRP compared to placebo in 48 healthy adults.
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