Why the study?
Does local myocardial distance (MCL) correlate with left ventricular volume in open-chest dogs?
Does local myocardial distance (MCL) correlate with left ventricular volume in open-chest dogs?
Local myocardial dimensions measured by ultrasonic elements strongly correlate with left ventricular volumes estimated by thermodilution in dogs.
Supports MCL as volume surrogate in canine models; leaves open human translation and clinical adoption.
AbstractUltrasonic elements inserted parallel to the surface of the anterior wall of the left ventricle in open-chest dogs were used to determine myocardial distances (MCL). During saline loading with and without administration of isoproterenol, end-systolic and end-diastolic MCL were compared with the corresponding ventricular volumes (ESV and EDV), estimated by thermodilution technique. In individual experiments, correlation coefficients for the relationship between MCL3and ventricular volumes ranged from 0.91 to 0.99. It is concluded that stroke volume can be analyzed in terms of end-systolic and end-diastolic MCL, and that the thermodilution technique correctly determines ESV/EDV.
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Lekven et al. (1972) studied this question.
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