Objective To investigate the short-term risk of intussusception following SARS-CoV-2 and adenovirus infections in children Study design Using Japan's health insurance claims database from January 2015 to December 2022, a self-controlled risk interval (SCRI) design and a nested case-control (NCC) analysis with conditional logistic regression were employed to adjust for individual confounders and assess the robustness of the findings. Results The study included 3.6 million children aged Conclusions This study provides population-scale evidence that both SARS-CoV-2 and adenovirus infections are associated with the risk of pediatric intussusception, with adenovirus demonstrating a stronger effect. The findings have implications for clinical vigilance and understanding the impact of viral infections on gastrointestinal disorders in children.
Miyamori et al. (Mon,) studied this question.