January 1, 2002Canadian Journal of Physiology and Pharmacology

Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression

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Population

Rats with myocardial infarction (MI)

Comparison

Omapatrilat or captopril started 4 hours… vs Untreated MI rats

Design

Preclinical

Follow-up

4 days

Authors

CBCharles BlaisUniversité de Montréal NLNathalie LapointeAegera Therapeutics (Canada)JRJean‐Lucien RouleauHeart Failure & Transplant

Discussion

Member takes

Implication

Rat model equivalence does not support altering post-MI ACEI therapy; leaves open human translation of dual NEP/ACE inhibition.

Structured PICO

Population

Rats with myocardial infarction (MI)

Intervention

Omapatrilat (10 and 40 mg/kg/day) or captopril (160 mg/kg/day) started 4 hours post-MI, with or without B1 and B2 kinin receptor antagonists (2.5 mg/kg/day each)

Comparator

Untreated MI rats

Outcome

Survival, cardiac hemodynamics (LVEDP, pulmonary congestion), and cytokine mRNA expression (TNF-alpha, TGF-beta1, IL-10) in left ventricular tissues at 4 days post-MIsurrogate

Omapatrilat and captopril similarly improve early post-MI survival and cardiac hemodynamics in a rat model, despite differing effects on cardiac cytokine expression.

Cite This Study

Blais et al. (2002) studied this question.

synapsesocial.com/papers/6a2115ac23521dddf4c3befd https://doi.org/10.1139/y01-096

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Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider