What question did this study set out to answer?

The aim was to evaluate the safety and effectiveness of THC-containing cannabis for anxiety based on controlled studies and randomized clinical trials.

June 4, 2026Journal of Affective Disorders ReportsOpen Access

Effectiveness and safety of cannabis on anxiety treatment outcomes: a systematic review

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Authors

PKPareeta KotechaCenter for Drug Evaluation and Research SPSilvia Pérez-VilarUnited States Food and Drug Administration JLJoshua LloydCenter for Drug Evaluation and Research

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Systematic review evaluating THC cannabis’ safety and effectiveness for anxiety treatment outcomes, indicating mixed findings.

Key Points

The aim was to evaluate the safety and effectiveness of THC-containing cannabis for anxiety based on controlled studies and randomized clinical trials.
Searched PubMed, Embase, APA PsychInfo, and Cochrane databases in February 2023.
Included controlled quantitative assessments of anxiety outcomes after cannabis treatment.
Assessed risk of bias using RoB2/ROBINS-I and evidence quality via GRADE.
The OCD RCT showed significant anxiety worsening [4.31 (1.70, 6.92)].
The Parkinson’s disease RCT showed non-significant improvement [-0.82 (-1.97, 0.33)].
Quality of life worsened with THC in Parkinson’s [-0.14 (-0.23, -0.04)].

Cite This Study

Kotecha et al. (2026) studied this question.

synapsesocial.com/papers/6a2115bdd499ed480b16eb2b https://doi.org/10.1016/j.jadr.2026.101095

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Effectiveness and safety of cannabis on anxiety treatment outcomes: a systematic review

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Key Points

Cite This Study

Effectiveness and safety of cannabis on anxiety treatment outcomes: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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