Glycoconjugated Re(CO) ₃ ⁺ complexes: syntheses, characterization, cytotoxicity and cellular localization

Bita Abdolahi Sanati; Ewan L. Gilleard; Tamara Teixeira; Małgorzata Korbas; Yasuhiro Niwa; Arvi Rauk; F x E bio R. P. Rocha; Farideh Jalilehvand

doi:10.1039/d6dt00710d

January 1, 2026Dalton TransactionsOpen Access

Glycoconjugated Re(CO) ₃ ⁺ complexes: syntheses, characterization, cytotoxicity and cellular localization

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Key Points

This research aims to evaluate the synthesis and cytotoxic properties of glycoconjugated Re(CO)3+ complexes in cancer cells.
Synthesized a stable, water-soluble glycoconjugated Re(CO)3+ complex.
Investigated the cytotoxic effects on A2780 ovarian cancer cells.
Examined cellular localization and uptake mechanisms mediated by glucose transport proteins.
The glycoconjugated complex showed significant accumulation in nuclear/perinuclear regions of A2780 cells.

Implication

Observes cytotoxicity and cellular localization in ovarian cancer cells, highlighting potential therapeutic pathways.

Abstract

A stable, water-soluble glycoconjugated fac -[Re(CO) 3 ( N , N ′)L] + complex showed significant accumulation in the nuclear/perinuclear regions of A2780 ovarian cancer cells; its uptake could be partially mediated by glucose transport proteins.

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Cite This Study

Sanati et al. (2026) studied this question.

synapsesocial.com/papers/6a2115bdd499ed480b16ecc6 https://doi.org/10.1039/d6dt00710d

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Glycoconjugated Re(CO) ₃ ⁺ complexes: syntheses, characterization, cytotoxicity and cellular localization

Key Points

Implication

Abstract

Discussion

Cite This Study

Glycoconjugated Re(CO) ₃ ⁺ complexes: syntheses, characterization, cytotoxicity and cellular localization

Key Points

Implication

Abstract

Discussion

Cite This Study

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