What question did this study set out to answer?

This analysis evaluates the efficacy of ixekizumab in patients with radiographic axial spondyloarthritis, stratified by baseline C-reactive protein levels.

June 4, 2026Rheumatology and TherapyOpen Access

Efficacy of Ixekizumab in Radiographic Axial Spondyloarthritis by Baseline C-Reactive Protein Level: A Pooled Analysis of Phase III Trials

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Authors

RSRaj SenguptaRoyal National Hospital for Rheumatic Diseases PMPedro M. MachadoLondon North West Healthcare NHS Trust PGPhilippe GoupilleUniversité de Tours

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Implication

Pooled analysis demonstrates IXE improves outcomes in r-axSpA regardless of baseline CRP levels, suggesting broad efficacy.

Key Points

This analysis evaluates the efficacy of ixekizumab in patients with radiographic axial spondyloarthritis, stratified by baseline C-reactive protein levels.
Post hoc analysis of biologic-naïve patients with r-axSpA from two phase III trials (NCT04285229, N = 130; COAST-V, N = 168).
Patients received ixekizumab 80 mg every 4 weeks or placebo for up to 52 weeks.
Outcomes assessed included ASAS40, ASDAS LDA/ID, and BASDAI50 based on baseline CRP levels.
By week 52, IXE improved ASAS40 in 61.2% (normal CRP) and 63.0% (elevated CRP) compared to placebo.
ASDAS LDA/ID was achieved in 69.4% (normal CRP) and 58.8% (elevated CRP) by week 52.
BASDAI50 improvements were noted in 55.1% (normal CRP) and 63.0% (elevated CRP) groups.

Cite This Study

Sengupta et al. (2026) studied this question.

synapsesocial.com/papers/6a2115d7d499ed480b16edf0 https://doi.org/10.1007/s40744-026-00862-1

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Efficacy of Ixekizumab in Radiographic Axial Spondyloarthritis by Baseline C-Reactive Protein Level: A Pooled Analysis of Phase III Trials

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Cite This Study

Efficacy of Ixekizumab in Radiographic Axial Spondyloarthritis by Baseline C-Reactive Protein Level: A Pooled Analysis of Phase III Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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