Randomized trial reveals decreased adipocyte differentiation in visceral fat contributes to metabolic dysfunction-associated liver disease.
Key Points
This research aims to explore the link between adipocyte differentiation in visceral adipose tissue and metabolic dysfunction-associated steatotic liver disease (MASLD).
Single nucleus RNA-sequencing used on adipose tissue biopsies to assess adipocyte differentiation.
Comparison of gene expression in visceral adipose tissue and subcutaneous adipose tissue among individuals with MASLD and obesity.
Heritability analysis of VAT adipocyte differentiation gene sets in relation to MASLD.
Predicted VAT adipocyte differentiation is significantly decreased in individuals with MASLD.
The differentiation gene set accounts for 17% of MASLD heritability, overlapping with differentially expressed adipocyte genes.
Associated adipocyte genes correlate with smaller adipocyte sizes.