Key result
Chronic repetitive ischemia in hibernating myocardium elicits an upregulation of anti-apoptotic, growth, and cytoprotective genes that protects against cell death and maintains tissue viability.
Why the study?
Does chronic repetitive ischemia elicit a gene program of survival protecting hibernating myocardium against cell death?
Population
Patients surgically treated for hibernating myocardium and a chronic swine model of repetitive ischemia
Comparison
Chronic repetitive ischemia vs Irreversibly injured myocardium
Design
Preclinical
Authors
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Highlights endogenous cytoprotective mechanisms in hibernating myocardium; hypothesis-generating for targeted ischemic therapies.
Observational
Does chronic repetitive ischemia elicit a gene program of survival protecting hibernating myocardium against cell death?
Demonstrates that an endogenous gene program of cell survival underlies the sustained viability of the hibernating heart, offering potential therapeutic targets for ischemic tissues.
Depré et al. (2004) conducted an observational in Hibernating myocardium in coronary artery disease. Chronic repetitive ischemia (hibernating myocardium) vs. Irreversibly injured myocardium was evaluated on Expression of survival genes and corresponding proteins. Chronic repetitive ischemia in hibernating myocardium elicits an upregulation of anti-apoptotic, growth, and cytoprotective genes that protects against cell death and maintains tissue viability.
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