April 1, 2003Open Access
The pathological basis of myocardial hibernation.
Population
Patients with coronary artery disease and myocardial hibernation
Design
Review
Authors
Discussion
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Member takes
Implication
May warrant early revascularization to limit fibrosis; extends morphological data but leaves optimal timing open for trials.
Structured PICO
P
Population
Patients with coronary artery disease and myocardial hibernation (persistent regional ventricular dysfunction reversible with revascularization)
Understanding the inflammatory and morphological changes in hibernating myocardium highlights the need for timely revascularization to prevent irreversible fibrosis and dysfunction.
Limitations
- Mechanistic studies on myocardial hibernation have been hampered by the difficulty in developing a reproducible and reliable animal model.
Cite This Study
Nikolaos G. Frangogiannis (2003) studied this question.