Asymmetric Aminocatalysis Combined with Iodine Catalysis: One-Pot Sequential Catalytic Approach to Access Chiral Spirodihydrobenzofuran-Pyrazolones

-hydroxy enones and pyrazolones. The desired products are realized in moderate to good yields with good diastereoselectivities and high enantioselectivities. This one-pot method features the formation of contiguous stereocenters, of which one is the spiro-quaternary stereocenter, engagement of less reactive electrophiles, mild reaction conditions, and scalability. Importantly, the reported protocol provides a mechanistically distinct pathway to construct enantioenriched spirodihydrobenzofuran-pyrazolones.