Demonstrates effective metal-free trifluoromethylthiolation in alkynes, implying a simpler synthesis method.
A metal-free electrophilic trifluoromethylthiolation/selenolation has been developed. Electrophilic SCF3/SeCF3 species generated from trifluoromethyl sulfoxide/selenoxide and Tf2O successfully couple with alkynes bearing pendant nucleophiles to obtain the corresponding trifluoromethylthiolation/selenolation and cyclization...
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Yang et al. (2026) studied this question.
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