This research demonstrates trifluoromethylselenolation and cyclization of alkenes, suggesting practical synthesis of heterocycles containing CF3Se.
In this study, we have developed the tandem trifluoromethylselenolation/cyclization of alkenes to synthesize the CF 3 Se‐containing heterocycles with trifluoromethyl selenoxide as the trifluoromethylselenolation reagent and Tf 2 O as the catalyst. This transformation featured mild conditions and easy operation. Both CF 3 Se‐containing oxindoles and benzoxazines could be obtained in useful yields. Based on the preliminary results and previous reports, a mechanism involving the generation of the electrophilic CF 3 Se species was proposed.
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Zhu et al. (2025) studied this question.
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