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This study aims to assess the management of anemia and iron deficiency in cancer patients undergoing chemotherapy in Japan.

Management of iron deficiency anemia and the role of intravenous iron supplementation in patients undergoing cancer chemotherapy: a real-world retrospective study in Japan

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This study aims to assess the management of anemia and iron deficiency in cancer patients undergoing chemotherapy in Japan.
Retrospective observational study of patients with solid tumors receiving chemotherapy from January 2015 to March 2025.
Evaluated hemoglobin levels, transferrin saturation, and serum ferritin both pre- and post-chemotherapy.
Analyzed anemia treatment status and changes in hemoglobin levels following intravenous iron supplementation.
75,603 patients included; 55.1% had baseline hemoglobin below normal limits.
Functional iron deficiency found in 54.8% of patients before chemotherapy, increasing to 61.6% after initiation.
Intravenous iron therapy was prescribed in < 3% of patients, with some showing increased hemoglobin after treatment.

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Retrospective study found high prevalence of anemia in cancer patients, indicating a need for better management practices.

Kosugi et al. (2026) studied this question.

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