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Plasma protein changes of acute tissue injury are seen in acute myocardial infarction, and the increase in hematocrit and blood viscosity represents increased strain on the heart. The phenomenon of intravascular sludging will appear, effecting either a temporary drop in viscosity or a more prolonged drop in both viscosity and hematocrit. Improved hydration alone does not reduce viscosity as measured, but dextran of low molecular weight significantly reduces blood viscosity during the period of its administration. This action should materially reduce the work of the heart and, in effect, rest it during this period of acute stress.
Benson et al. (Sun,) studied this question.