Key result
A review of central dopaminergic systems yielded a new hypothesis regarding the electrophysiological functioning of midbrain dopamine systems in disorders like Parkinson's disease and schizophrenia.
This review synthesizes 20 years of research to propose a new hypothesis on the electrophysiological functioning of midbrain dopamine systems in neurological and mental disorders.
Hypothesis-generating for midbrain dopamine electrophysiology in Parkinson's and schizophrenia; leaves open validation before any clinical application.
The pathogenesis of a variety of neurological and mental disorders has been attributed to the malfunctioning of central dopaminergic systems. Twenty years of investigation concerning the way that dopamine systems function in the brain has yielded a great deal of information about the control and behavior of these systems. This collection of seemingly disparate facts is reviewed. A hypothesis is then presented that attempts to synthesize from these facts a view of the electrophysiological functioning of midbrain dopamine systems that may be helpful in understanding brain mechanisms underlying the pathology of such disorders as Parkinson's disease and schizophrenia.
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Bunney et al. (1991) conducted a review in Neurological and mental disorders (e.g., Parkinson's disease, schizophrenia). Midbrain dopamine system electrophysiological functioning was evaluated. A review of central dopaminergic systems yielded a new hypothesis regarding the electrophysiological functioning of midbrain dopamine systems in disorders like Parkinson's disease and schizophrenia.
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