New magnetic nanomaterials have been obtained on the basis of Fe3O4 nanoparticles modified with iron and silicon glycerolates and loaded with doxorubicin. Nanogels have been prepared by dispersing the modified nanoparticles (0.1 and 0.3 wt %) in a water–glycerol medium (optimal glycerol concentration of 30 wt %), including the presence of chitosan (1.0 wt %) and doxorubicin (0.3 wt %). The obtained nanoconjugates with doxorubicin have been characterized by physicochemical methods, including IR spectroscopy, transmission electron microscopy, dynamic light scattering, etc. It has been shown that chitosan promotes drug sorption: the addition of chitosan at an initial nanoparticle concentration of 0.1 wt % increases the doxorubicin content in the nanoconjugate (LC) from 25.5 to 30.8 wt % and the sorption efficiency (LE) from 11.4 to 14.9 wt %; at an initial nanoparticle concentration of 0.3 wt %, the LE increases from 12.0 to 14.4 wt %, and LC grows from 10.7 to 12.6 wt %. As a result, the optimal composition of the nanoconjugate is achieved by immobilizing the drug from a water–glycerol medium containing the modified Fe3O4 nanoparticles (0.1 wt %), chitosan (1.0 wt %), and doxorubicin (0.3 wt %). This material seems to be promising for further research as a local instillation agent for chemotherapy in oncourology.
Frolova et al. (Mon,) studied this question.