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June 4, 2026Physical Chemistry Chemical Physics0 citationsOpen Access

Deciphering the Temporal and Spatial Mutation Dynamics of the SARS-CoV-2 Spike Glycoprotein

MHMuhammad HasanSCShihong ChenMJMengqi Jia

Key Points

  • This research aims to understand the mutation dynamics of the SARS-CoV-2 spike glycoprotein across time and space.
  • Developed a statistical pipeline with two analysis procedures
  • Conducted probability sequence density analysis to explore spike mutation sequence space
  • Identified leading mutations in the spike glycoprotein
  • Identified significant patterns in the temporal mutation dynamics of the spike glycoprotein
  • Detected key mutations influencing viral adaptation
  • Revealed spatial variations in mutation occurrences across different regions

Abstract

We present a statistical pipeline with two parallel procedures to analyze SARS-CoV-2 spike evolution: (1) probability sequence density analysis for probing its sequence space, and (2) leading mutations by the...

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Cite This Study

Hasan et al. (2026) studied this question.

synapsesocial.com/papers/6a21171dd499ed480b16ff4fhttps://doi.org/10.1039/d5cp04811g
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