Key result
RF ablation guided by 3D open-window mapping successfully treats WPW syndrome in dextrocardia.
Why the study?
The coexistence of dextrocardia and Wolff-Parkinson-White syndrome is exceedingly rare and presents unique challenges for electrophysiological mapping and ablation.
Case Report (n=1)
Three-dimensional open-window mapping combined with the EASY-WPW algorithm is feasible and effective for guiding radiofrequency ablation of WPW syndrome in patients with complex anatomic variants like dextrocardia with situs inversus.
May support 3D mapping for WPW in dextrocardia; leaves open validation in larger cohorts before practice change.
The coexistence of dextrocardia and Wolff-Parkinson-White (WPW) syndrome is exceedingly rare and presents unique challenges for electrophysiological mapping and ablation. We report the first successful radiofrequency catheter ablation guided by three-dimensional open-window mapping (OWM) in such a patient. Pre-procedural right-sided electrocardiography analyzed with the EASY-WPW algorithm predicted a right inferoparaseptal accessory pathway, consistent with OWM localization. Despite reversed cardiac anatomy, precise mapping enabled effective ablation without complications. This case illustrates the feasibility of three-dimensional OWM-guided ablation in complex anatomic variants and highlights the complementary role of the EASY-WPW algorithm in accurately predicting accessory pathway locations before intervention.
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Huang et al. (2026) conducted a case report in Wolff-Parkinson-White syndrome with dextrocardia and situs inversus (n=1). Radiofrequency catheter ablation guided by three-dimensional open-window mapping was evaluated on Successful ablation without complications. Radiofrequency catheter ablation guided by three-dimensional open-window mapping successfully treated Wolff-Parkinson-White syndrome in a patient with dextrocardia without complications.
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