Cost-Effectiveness of a Novel Antitachycardia Pacing Algorithm for the Termination of Ventricular Tachyarrhythmias in the United States

Figures

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  Figure 1. Markov model diagram. A Markov model showing the simulation of the time course of patients receiving an ICD with either iATP or conventional ATP capability. Ovals represent model states; arrows indicate transitions between states. For detailed model information, refer to Methods and Supplemental Data 1. ATP = antitachycardia pacing; iATP = intrinsic antitachycardia pacing; ICD = implantable cardioverter-defibrillator; VT/VF = ventricular tachycardia/ventricular fibrillation.

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  Figure 2. Deterministic sensitivity analysis tornado diagram. The outer ends of the dark bars represent ICER values using the upper bound of the relevant model input while holding other inputs at the base-case value. The outer ends of the light bars use the lower bound of the relevant model input. ICER = incremental cost-effectiveness ratio; QALY = quality-adjusted life-year; other abbreviations as in Figure 1.

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  Figure 3. Probabilistic sensitivity analysis scatterplot. The range of ICER given probabilistic variation in model inputs. Dots represent individual ICER data points; the red line represents the WTP. All ICER values below and to the right of the red line are below the WTP threshold. The green triangle denotes a point composed of the average of all values on the x-axis (Incremental QALYs) and the average of all values on the y-axis (incremental costs). CE = cost effectiveness; PSA = probabilistic sensitivity analysis; WTP = willingness-to-pay; other abbreviations as in Figures 1 and 2.

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  Figure 4. Cost-effectiveness acceptability curves. The curves represent the probability that the incremental cost-effectiveness ratio falls below each willingness-to-pay threshold (x-axis) based on probabilistic sensitivity analysis simulations. The curves cross at 50% on the y-axis, and to the right, all values indicate that iATP cost-effectiveness is more probable. Abbreviations as in Figure 1.