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This review evaluates chlorhexidine-based disinfection protocols for reducing microbial load on complete dentures.

June 4, 2026OdontologyOpen Access

Chlorhexidine-based protocols for complete denture disinfection: a systematic review and meta-analysis

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Systematic review evaluates chlorhexidine antiseptic effectiveness for denture disinfection, suggesting improved protocols are needed.

This review evaluates chlorhexidine-based disinfection protocols for reducing microbial load on complete dentures.
Systematic review including 22 clinical studies and 5 meta-analysis studies
Data sourced from multiple databases and gray literature until September 2024
Meta-analysis conducted to compare effectiveness of chlorhexidine concentrations and application methods.
Chlorhexidine at 0.12% showed significant CFU reduction of -1.11 (95% CI: -1.57 to -0.64; p < 0.00001) over 7 days
Chlorhexidine at 0.2% resulted in a CFU reduction of -2.50 (95% CI: -4.57 to -0.43; p = 0.02) over 30 days
Pooled analysis indicated a significant microbial reduction of -1.66 (95% CI: -2.75 to -0.57; p < 0.003) over time.

Soto et al. (2026) studied this question.

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