What question did this study set out to answer?

This study aimed to investigate metabolite ratios in specific brain regions and their associations with cognitive and emotional features in Parkinson’s Disease.

June 4, 2026Journal of Clinical MedicineOpen Access

Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson’s Disease: An Exploratory 1H-MRS Study of the Substantia Nigra and Globus Pallidus

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Authors

LCLaura CulicettoCentro Neurolesi Bonino Pulejo GMGiulia MarafiotiCentro Neurolesi Bonino Pulejo LBLilla BonannoCentro Neurolesi Bonino Pulejo

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Exploratory trial examines metabolite ratios in brain structures and their association with cognition in Parkinson’s Disease.

Key Points

This study aimed to investigate metabolite ratios in specific brain regions and their associations with cognitive and emotional features in Parkinson’s Disease.
Fifteen individuals with Parkinson’s Disease and 15 healthy controls underwent Proton Magnetic Resonance Spectroscopy targeting SN and GP.
Metabolite ratios were quantified using LCModel and analyzed across groups and hemispheres.
Participants completed assessments for motor severity, cognition, visuospatial abilities, mood, and alexithymia.
PD participants showed significantly lower MoCA scores than HCs (20.9 ± 6.6 vs. 28.7 ± 1.8; FDR-corrected p < 0.001).
Uncorrected comparisons revealed lower myo-inositol in the SN (p = 0.04) and higher glutamatergic signal in the right GP of PD relative to HCs (p = 0.03).
No findings survived FDR correction, indicating the need for larger studies.

Cite This Study

Culicetto et al. (2026) studied this question.

synapsesocial.com/papers/6a2117dfd499ed480b170aae https://doi.org/10.3390/jcm15114236

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Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson’s Disease: An Exploratory 1H-MRS Study of the Substantia Nigra and Globus Pallidus

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Cite This Study

Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson’s Disease: An Exploratory 1H-MRS Study of the Substantia Nigra and Globus Pallidus

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